Cook the bacon until crispy. Remove and set onto a paper towel lined plate. Keep the bacon grease in the pan.
Add the chopped onions and Serrano pepper to the pan. Sauté for 10 minutes to soften. Roughly chop the bacon in the meantime.
Combine ground beef, bacon, onion, Serrano pepper, Panko, pepper, paprika, and chili powder in a large mixing bowl. Mix well.
In a small mixing bowl, combine the egg, ¼ cup bbq sauce, Worcestershire, and liquid smoke. Whisk. Pour into the ground beef mixture and mix until thoroughly combined.
Lightly spray a loaf pan with non-stick cooking spray. Add the meat to the pan.
Place into the oven on the center rack. Bake for 40 minutes.
Remove from the oven. Take the meatloaf out of the loaf pan and place onto a baking sheet. Brush the top and sides of the meatloaf with bbq sauce. Place back into the oven for 20 minutes.